Hypertension is a major and growing worldwide health concern. Because of its effects on end organs and its links to chronic renal disease, diabetes mellitus, and obesity, it is a primary reason for cardiovascular disease and early mortality globally. Existing antihypertensive medicines can be used more effectively, while therapies developed for co-existing illnesses (such as sodium-glucose transporter 2 inhibitors for diabetes mellitus) can provide further BP-lowering and cardiovascular advantages. Stress, it is now well recognized that chronic illnesses typically present with many forms of psychopathology, including depressive symptoms, cognitive-behavioral problems, sleep disturbances, and excessively high levels of stress. Stress-related psychological corollaries, such as increased anxiety, sadness, or rage, are established predictors of hypertension. Stress is connected with autonomic nervous system hyperactivity, hypothalamic pituitary adrenal axis dysregulation, and maladaptive lifestyle variables such as nicotine, hard liquor use, obesity, and lack of exercise.
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